Benign and efficient preparation of thioethers by solvent-free S-alkylation of thiols with alkyl halides catalyzed by potassium fluoride on alumina

Kha Ngoc Nguyen, Fritz Duus, Thi Xuan Thi Luu

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

The preparation of thioethers by S-alkylation of various thiols with alkyl halides under solvent-free reaction conditions using potassium fluoride on alumina (KF/Al2O3) as a solid catalyst has been investigated in detail with respect to three different modes of reaction activation (ultrasound irradiation, microwave irradiation, and conventional heating) for obtaining maximum yield of the thioether. The importance of KF/Al2O3 as a particularly efficient catalyst was corroborated for all three modes of reaction activation, although the reaction time was found to be strongly dependent on the mode of activation. The yield of the thioethers was also found to depend on the amount of the solid catalyst relative to the equimolar amounts of the two reactants.
OriginalsprogEngelsk
TidsskriftJournal of Sulfur Chemistry
Vol/bind37
Udgave nummer3
Sider (fra-til)349-360
ISSN1741-5993
DOI
StatusUdgivet - 2016

Citer dette

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title = "Benign and efficient preparation of thioethers by solvent-free S-alkylation of thiols with alkyl halides catalyzed by potassium fluoride on alumina",
abstract = "The preparation of thioethers by S-alkylation of various thiols with alkyl halides under solvent-free reaction conditions using potassium fluoride on alumina (KF/Al2O3) as a solid catalyst has been investigated in detail with respect to three different modes of reaction activation (ultrasound irradiation, microwave irradiation, and conventional heating) for obtaining maximum yield of the thioether. The importance of KF/Al2O3 as a particularly efficient catalyst was corroborated for all three modes of reaction activation, although the reaction time was found to be strongly dependent on the mode of activation. The yield of the thioethers was also found to depend on the amount of the solid catalyst relative to the equimolar amounts of the two reactants.",
keywords = "Potassium fluoride on alumina, thioether, ultrasouns irradiation, microwave irradiation, solvent-free reaction",
author = "Nguyen, {Kha Ngoc} and Fritz Duus and Luu, {Thi Xuan Thi}",
year = "2016",
doi = "10.1080/17415993.2016.1150483",
language = "English",
volume = "37",
pages = "349--360",
journal = "Journal of Sulfur Chemistry",
issn = "1741-5993",
publisher = "Taylor & Francis",
number = "3",

}

Benign and efficient preparation of thioethers by solvent-free S-alkylation of thiols with alkyl halides catalyzed by potassium fluoride on alumina. / Nguyen, Kha Ngoc; Duus, Fritz; Luu, Thi Xuan Thi.

I: Journal of Sulfur Chemistry, Bind 37, Nr. 3, 2016, s. 349-360.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Benign and efficient preparation of thioethers by solvent-free S-alkylation of thiols with alkyl halides catalyzed by potassium fluoride on alumina

AU - Nguyen, Kha Ngoc

AU - Duus, Fritz

AU - Luu, Thi Xuan Thi

PY - 2016

Y1 - 2016

N2 - The preparation of thioethers by S-alkylation of various thiols with alkyl halides under solvent-free reaction conditions using potassium fluoride on alumina (KF/Al2O3) as a solid catalyst has been investigated in detail with respect to three different modes of reaction activation (ultrasound irradiation, microwave irradiation, and conventional heating) for obtaining maximum yield of the thioether. The importance of KF/Al2O3 as a particularly efficient catalyst was corroborated for all three modes of reaction activation, although the reaction time was found to be strongly dependent on the mode of activation. The yield of the thioethers was also found to depend on the amount of the solid catalyst relative to the equimolar amounts of the two reactants.

AB - The preparation of thioethers by S-alkylation of various thiols with alkyl halides under solvent-free reaction conditions using potassium fluoride on alumina (KF/Al2O3) as a solid catalyst has been investigated in detail with respect to three different modes of reaction activation (ultrasound irradiation, microwave irradiation, and conventional heating) for obtaining maximum yield of the thioether. The importance of KF/Al2O3 as a particularly efficient catalyst was corroborated for all three modes of reaction activation, although the reaction time was found to be strongly dependent on the mode of activation. The yield of the thioethers was also found to depend on the amount of the solid catalyst relative to the equimolar amounts of the two reactants.

KW - Potassium fluoride on alumina

KW - thioether

KW - ultrasouns irradiation

KW - microwave irradiation

KW - solvent-free reaction

U2 - 10.1080/17415993.2016.1150483

DO - 10.1080/17415993.2016.1150483

M3 - Journal article

VL - 37

SP - 349

EP - 360

JO - Journal of Sulfur Chemistry

JF - Journal of Sulfur Chemistry

SN - 1741-5993

IS - 3

ER -