Type 2 diabetes (T2DM) has been related to lifestyle, obesity and age; however, T2DM has also been associated with mitochondrial dysfunction. Mitochondria produce ATP and during this synthesis, reactive oxygen species are generated. Increased levels of reactive oxygen species are associated with development of diabetic complications. ATP-synthesis and ROS-generation are dependent on mitochondrial membrane potential (MMP), which indicate the activity of the mitochondria.
|Status||Udgivet - 2014|