Are invertebrates relevant models in ageing research?

Focus on the effects of rapamycin on TOR

Cihan Suleyman Erdogan, Benni Winding Hansen, Ole Vang

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Ageing is the organisms increased susceptibility to death, which is linked to accumulated damage in the cells and tissues. Ageing is a complex process regulated by crosstalk of various pathways in the cells. Ageing is highly regulated by the Target of Rapamycin (TOR) pathway activity. TOR is an evolutionary conserved key protein kinase in the TOR pathway that regulates growth, proliferation and cell metabolism in response to nutrients, growth factors and stress. Comparing the ageing process in invertebrate model organisms with relatively short lifespan with mammals provides valuable information about the molecular mechanisms underlying the ageing process faster than mammal systems. Inhibition of the TOR pathway activity via either genetic manipulation or rapamycin increases lifespan profoundly in most invertebrate model organisms. This contribution will review the recent findings in invertebrates concerning the TOR pathway and effects of TOR inhibition by rapamycin on lifespan. Besides some contradictory results, the majority points out that rapamycin induces longevity. This suggests that administration of rapamycin in invertebrates is a promising tool for pursuing the scientific puzzle of lifespan prolongation.
OriginalsprogEngelsk
TidsskriftMechanisms of Ageing and Development
Vol/bind153
Sider (fra-til)22-29
ISSN0047-6374
DOI
StatusUdgivet - jan. 2016

Citer dette

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Are invertebrates relevant models in ageing research? Focus on the effects of rapamycin on TOR. / Erdogan, Cihan Suleyman; Hansen, Benni Winding; Vang, Ole.

I: Mechanisms of Ageing and Development, Bind 153, 01.2016, s. 22-29.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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AB - Ageing is the organisms increased susceptibility to death, which is linked to accumulated damage in the cells and tissues. Ageing is a complex process regulated by crosstalk of various pathways in the cells. Ageing is highly regulated by the Target of Rapamycin (TOR) pathway activity. TOR is an evolutionary conserved key protein kinase in the TOR pathway that regulates growth, proliferation and cell metabolism in response to nutrients, growth factors and stress. Comparing the ageing process in invertebrate model organisms with relatively short lifespan with mammals provides valuable information about the molecular mechanisms underlying the ageing process faster than mammal systems. Inhibition of the TOR pathway activity via either genetic manipulation or rapamycin increases lifespan profoundly in most invertebrate model organisms. This contribution will review the recent findings in invertebrates concerning the TOR pathway and effects of TOR inhibition by rapamycin on lifespan. Besides some contradictory results, the majority points out that rapamycin induces longevity. This suggests that administration of rapamycin in invertebrates is a promising tool for pursuing the scientific puzzle of lifespan prolongation

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