Apathy in first episode psychosis patients: a ten year longitudinal follow-up study

Erik Simonsen, Julie Evensen, Jan Ivar Røsberg, Helene Barder, Ulrik Haahr, Wenche ten Welden Hegelstad, Inge Joa, Jan Olav Johannessen, Tor Ketil Larsen, Ingrid Melle, Stein Opjordsmoen, Bjørn Rishovd Rund, Ketil Sundet, Per Vaglum, Svein Friis, Thomas McGlashan

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    Resumé

    BACKGROUND:

    Apathy is a common symptom in first episode psychosis (FEP), and is associated with poor functioning. Prevalence and correlates of apathy 10 years after the first psychotic episode remain unexplored.

    OBJECTIVE:

    The aims of the study were twofold: 1) to examine prevalence and predictors of apathy at 10 years, and 2) to examine the relationship between apathy at 10 years and concurrent symptoms, functioning and outcome, including subjective quality of life.

    METHODS:

    Three-hundred-and-one patients with FEP were included at baseline, 186 participated in the 10 year follow-up. Of these, 178 patients completed the Apathy Evaluation Scale (AES-S-Apathy). Patients were classified as having apathy (AES-S-Apathy≥27) or not. The relationship between apathy and baseline variables (Demographics, Diagnosis, Duration of Untreated Psychosis), measures of symptomatology (Positive and Negative Syndrome Scale, Calgary Depression Scale for Schizophrenia), functioning (Global Assessment of Functioning Scale, Strauss Carpenter Level of Functioning Scale) and subjective quality of life (Lehman's Quality of Life Interview) were estimated through correlation analyses and blockwise multiple hierarchical regression analysis.

    RESULTS:

    Nearly 30% of patients met the threshold for being apathetic at follow-up. No baseline variables predicted apathy significantly at 10 years. Apathy was found to contribute independently to functioning and subjective quality of life, even when controlling for other significant correlates.

    CONCLUSIONS:

    Apathy is a common symptom in a FEP cohort 10 years after illness debut, and its presence relates to impaired functioning and poorer subjective quality of life.
    OriginalsprogEngelsk
    TidsskriftSchizophrenia Research
    Vol/bind136
    Udgave nummer1-3
    Sider (fra-til)19-24
    ISSN0920-9964
    DOI
    StatusUdgivet - 2012

    Citer dette

    Simonsen, E., Evensen, J., Røsberg, J. I., Barder, H., Haahr, U., Hegelstad, W. T. W., ... McGlashan, T. (2012). Apathy in first episode psychosis patients: a ten year longitudinal follow-up study. Schizophrenia Research, 136(1-3), 19-24. https://doi.org/10.1016/j.schres.2011.12.019
    Simonsen, Erik ; Evensen, Julie ; Røsberg, Jan Ivar ; Barder, Helene ; Haahr, Ulrik ; Hegelstad, Wenche ten Welden ; Joa, Inge ; Johannessen, Jan Olav ; Larsen, Tor Ketil ; Melle, Ingrid ; Opjordsmoen, Stein ; Rund, Bjørn Rishovd ; Sundet, Ketil ; Vaglum, Per ; Friis, Svein ; McGlashan, Thomas. / Apathy in first episode psychosis patients: a ten year longitudinal follow-up study. I: Schizophrenia Research. 2012 ; Bind 136, Nr. 1-3. s. 19-24.
    @article{b063772c2ad74862b63df7a207c46bf6,
    title = "Apathy in first episode psychosis patients: a ten year longitudinal follow-up study",
    abstract = "BACKGROUND: Apathy is a common symptom in first episode psychosis (FEP), and is associated with poor functioning. Prevalence and correlates of apathy 10 years after the first psychotic episode remain unexplored.OBJECTIVE: The aims of the study were twofold: 1) to examine prevalence and predictors of apathy at 10 years, and 2) to examine the relationship between apathy at 10 years and concurrent symptoms, functioning and outcome, including subjective quality of life.METHODS: Three-hundred-and-one patients with FEP were included at baseline, 186 participated in the 10 year follow-up. Of these, 178 patients completed the Apathy Evaluation Scale (AES-S-Apathy). Patients were classified as having apathy (AES-S-Apathy≥27) or not. The relationship between apathy and baseline variables (Demographics, Diagnosis, Duration of Untreated Psychosis), measures of symptomatology (Positive and Negative Syndrome Scale, Calgary Depression Scale for Schizophrenia), functioning (Global Assessment of Functioning Scale, Strauss Carpenter Level of Functioning Scale) and subjective quality of life (Lehman's Quality of Life Interview) were estimated through correlation analyses and blockwise multiple hierarchical regression analysis.RESULTS: Nearly 30{\%} of patients met the threshold for being apathetic at follow-up. No baseline variables predicted apathy significantly at 10 years. Apathy was found to contribute independently to functioning and subjective quality of life, even when controlling for other significant correlates.CONCLUSIONS: Apathy is a common symptom in a FEP cohort 10 years after illness debut, and its presence relates to impaired functioning and poorer subjective quality of life.",
    author = "Erik Simonsen and Julie Evensen and R{\o}sberg, {Jan Ivar} and Helene Barder and Ulrik Haahr and Hegelstad, {Wenche ten Welden} and Inge Joa and Johannessen, {Jan Olav} and Larsen, {Tor Ketil} and Ingrid Melle and Stein Opjordsmoen and Rund, {Bj{\o}rn Rishovd} and Ketil Sundet and Per Vaglum and Svein Friis and Thomas McGlashan",
    year = "2012",
    doi = "10.1016/j.schres.2011.12.019",
    language = "English",
    volume = "136",
    pages = "19--24",
    journal = "Schizophrenia Research",
    issn = "0920-9964",
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    number = "1-3",

    }

    Simonsen, E, Evensen, J, Røsberg, JI, Barder, H, Haahr, U, Hegelstad, WTW, Joa, I, Johannessen, JO, Larsen, TK, Melle, I, Opjordsmoen, S, Rund, BR, Sundet, K, Vaglum, P, Friis, S & McGlashan, T 2012, 'Apathy in first episode psychosis patients: a ten year longitudinal follow-up study', Schizophrenia Research, bind 136, nr. 1-3, s. 19-24. https://doi.org/10.1016/j.schres.2011.12.019

    Apathy in first episode psychosis patients: a ten year longitudinal follow-up study. / Simonsen, Erik; Evensen, Julie; Røsberg, Jan Ivar; Barder, Helene; Haahr, Ulrik; Hegelstad, Wenche ten Welden; Joa, Inge; Johannessen, Jan Olav; Larsen, Tor Ketil; Melle, Ingrid; Opjordsmoen, Stein; Rund, Bjørn Rishovd; Sundet, Ketil; Vaglum, Per; Friis, Svein; McGlashan, Thomas.

    I: Schizophrenia Research, Bind 136, Nr. 1-3, 2012, s. 19-24.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    TY - JOUR

    T1 - Apathy in first episode psychosis patients: a ten year longitudinal follow-up study

    AU - Simonsen, Erik

    AU - Evensen, Julie

    AU - Røsberg, Jan Ivar

    AU - Barder, Helene

    AU - Haahr, Ulrik

    AU - Hegelstad, Wenche ten Welden

    AU - Joa, Inge

    AU - Johannessen, Jan Olav

    AU - Larsen, Tor Ketil

    AU - Melle, Ingrid

    AU - Opjordsmoen, Stein

    AU - Rund, Bjørn Rishovd

    AU - Sundet, Ketil

    AU - Vaglum, Per

    AU - Friis, Svein

    AU - McGlashan, Thomas

    PY - 2012

    Y1 - 2012

    N2 - BACKGROUND: Apathy is a common symptom in first episode psychosis (FEP), and is associated with poor functioning. Prevalence and correlates of apathy 10 years after the first psychotic episode remain unexplored.OBJECTIVE: The aims of the study were twofold: 1) to examine prevalence and predictors of apathy at 10 years, and 2) to examine the relationship between apathy at 10 years and concurrent symptoms, functioning and outcome, including subjective quality of life.METHODS: Three-hundred-and-one patients with FEP were included at baseline, 186 participated in the 10 year follow-up. Of these, 178 patients completed the Apathy Evaluation Scale (AES-S-Apathy). Patients were classified as having apathy (AES-S-Apathy≥27) or not. The relationship between apathy and baseline variables (Demographics, Diagnosis, Duration of Untreated Psychosis), measures of symptomatology (Positive and Negative Syndrome Scale, Calgary Depression Scale for Schizophrenia), functioning (Global Assessment of Functioning Scale, Strauss Carpenter Level of Functioning Scale) and subjective quality of life (Lehman's Quality of Life Interview) were estimated through correlation analyses and blockwise multiple hierarchical regression analysis.RESULTS: Nearly 30% of patients met the threshold for being apathetic at follow-up. No baseline variables predicted apathy significantly at 10 years. Apathy was found to contribute independently to functioning and subjective quality of life, even when controlling for other significant correlates.CONCLUSIONS: Apathy is a common symptom in a FEP cohort 10 years after illness debut, and its presence relates to impaired functioning and poorer subjective quality of life.

    AB - BACKGROUND: Apathy is a common symptom in first episode psychosis (FEP), and is associated with poor functioning. Prevalence and correlates of apathy 10 years after the first psychotic episode remain unexplored.OBJECTIVE: The aims of the study were twofold: 1) to examine prevalence and predictors of apathy at 10 years, and 2) to examine the relationship between apathy at 10 years and concurrent symptoms, functioning and outcome, including subjective quality of life.METHODS: Three-hundred-and-one patients with FEP were included at baseline, 186 participated in the 10 year follow-up. Of these, 178 patients completed the Apathy Evaluation Scale (AES-S-Apathy). Patients were classified as having apathy (AES-S-Apathy≥27) or not. The relationship between apathy and baseline variables (Demographics, Diagnosis, Duration of Untreated Psychosis), measures of symptomatology (Positive and Negative Syndrome Scale, Calgary Depression Scale for Schizophrenia), functioning (Global Assessment of Functioning Scale, Strauss Carpenter Level of Functioning Scale) and subjective quality of life (Lehman's Quality of Life Interview) were estimated through correlation analyses and blockwise multiple hierarchical regression analysis.RESULTS: Nearly 30% of patients met the threshold for being apathetic at follow-up. No baseline variables predicted apathy significantly at 10 years. Apathy was found to contribute independently to functioning and subjective quality of life, even when controlling for other significant correlates.CONCLUSIONS: Apathy is a common symptom in a FEP cohort 10 years after illness debut, and its presence relates to impaired functioning and poorer subjective quality of life.

    U2 - 10.1016/j.schres.2011.12.019

    DO - 10.1016/j.schres.2011.12.019

    M3 - Journal article

    VL - 136

    SP - 19

    EP - 24

    JO - Schizophrenia Research

    JF - Schizophrenia Research

    SN - 0920-9964

    IS - 1-3

    ER -

    Simonsen E, Evensen J, Røsberg JI, Barder H, Haahr U, Hegelstad WTW et al. Apathy in first episode psychosis patients: a ten year longitudinal follow-up study. Schizophrenia Research. 2012;136(1-3):19-24. https://doi.org/10.1016/j.schres.2011.12.019