Antibiofilm Peptides and Peptidomimetics with Focus on Surface Immobilization

Athina Andrea, Natalia Molchanova, Håvard Jenssen

Publikation: Bidrag til tidsskriftReviewForskningpeer review

Resumé

Bacterial biofilms pose a major threat to public health, as they are associated with at least two thirds of all infections. They are highly resilient and render conventional antibiotics inefficient. As a part of the innate immune system, antimicrobial peptides have drawn attention within the last decades, as some of them are able to eradicate biofilms at sub-minimum inhibitory concentration (MIC) levels. However, peptides possess a number of disadvantages, such as susceptibility to proteolytic degradation, pH and/or salinity-dependent activity and loss of activity due to binding to serum proteins. Hence, proteolytically stable peptidomimetics were designed to overcome these drawbacks. This paper summarizes the current peptide and peptidomimetic strategies for combating bacteria-associated biofilm infections, both in respect to soluble and surface-functionalized solutions.
OriginalsprogEngelsk
ArtikelnummerE27
TidsskriftBiomolecules
Vol/bind8
Udgave nummer2
ISSN2218-273X
StatusUdgivet - 2018

Citer dette

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abstract = "Bacterial biofilms pose a major threat to public health, as they are associated with at least two thirds of all infections. They are highly resilient and render conventional antibiotics inefficient. As a part of the innate immune system, antimicrobial peptides have drawn attention within the last decades, as some of them are able to eradicate biofilms at sub-minimum inhibitory concentration (MIC) levels. However, peptides possess a number of disadvantages, such as susceptibility to proteolytic degradation, pH and/or salinity-dependent activity and loss of activity due to binding to serum proteins. Hence, proteolytically stable peptidomimetics were designed to overcome these drawbacks. This paper summarizes the current peptide and peptidomimetic strategies for combating bacteria-associated biofilm infections, both in respect to soluble and surface-functionalized solutions.",
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Antibiofilm Peptides and Peptidomimetics with Focus on Surface Immobilization. / Andrea, Athina; Molchanova, Natalia; Jenssen, Håvard.

I: Biomolecules, Bind 8, Nr. 2, E27, 2018.

Publikation: Bidrag til tidsskriftReviewForskningpeer review

TY - JOUR

T1 - Antibiofilm Peptides and Peptidomimetics with Focus on Surface Immobilization

AU - Andrea, Athina

AU - Molchanova, Natalia

AU - Jenssen, Håvard

PY - 2018

Y1 - 2018

N2 - Bacterial biofilms pose a major threat to public health, as they are associated with at least two thirds of all infections. They are highly resilient and render conventional antibiotics inefficient. As a part of the innate immune system, antimicrobial peptides have drawn attention within the last decades, as some of them are able to eradicate biofilms at sub-minimum inhibitory concentration (MIC) levels. However, peptides possess a number of disadvantages, such as susceptibility to proteolytic degradation, pH and/or salinity-dependent activity and loss of activity due to binding to serum proteins. Hence, proteolytically stable peptidomimetics were designed to overcome these drawbacks. This paper summarizes the current peptide and peptidomimetic strategies for combating bacteria-associated biofilm infections, both in respect to soluble and surface-functionalized solutions.

AB - Bacterial biofilms pose a major threat to public health, as they are associated with at least two thirds of all infections. They are highly resilient and render conventional antibiotics inefficient. As a part of the innate immune system, antimicrobial peptides have drawn attention within the last decades, as some of them are able to eradicate biofilms at sub-minimum inhibitory concentration (MIC) levels. However, peptides possess a number of disadvantages, such as susceptibility to proteolytic degradation, pH and/or salinity-dependent activity and loss of activity due to binding to serum proteins. Hence, proteolytically stable peptidomimetics were designed to overcome these drawbacks. This paper summarizes the current peptide and peptidomimetic strategies for combating bacteria-associated biofilm infections, both in respect to soluble and surface-functionalized solutions.

KW - Antibiofilm

KW - Peptidomimetics

KW - Surface-immobilized peptides

M3 - Review

VL - 8

JO - Biomolecules

JF - Biomolecules

SN - 2218-273X

IS - 2

M1 - E27

ER -