Alcohol drinking habits, alcohol dehydrogenase genotypes and risk of acute coronary syndrome

Janne Schurmann Tolstrup, Jane Lindschou Hansen, Morten Grønbæk , Ulla Vogel, Anne Tjønneland, Albert Marni Joensen, Kim Overvad

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    Resumé

    Aims: The risk of myocardial infarction is lower among light-to-moderate drinkers compared with abstainers. Results from some previous studies, but not all, suggest that this association is modified by variations in genes coding for alcohol dehydrogenase (ADH).We aimed to test this hypothesis, including alcohol as both the amount of alcohol and the frequency of drinking. Methods: we conducted a nested case-cohort study within the Danish Diet, Cancer and Health study, including 1,645 men (770 incident cases of acute coronary syndrome from 1993–1997 through 2004 and 875 randomly selected controls). Results: Higher alcohol intake (measured as amount or drinking frequency) was associated with lower risk of acute coronary syndrome; however, there was no evidence that these finding were modified by ADH1B or ADH1C genotypes.
    Conclusions: The importance of functional variation in alcohol dehydrogenase for the association between alcohol drinking habits and the risk of developing acute coronary syndrome, if any, is very limited.
    OriginalsprogEngelsk
    TidsskriftScandinavian Journal of Public Health
    Vol/bind38
    Udgave nummer5
    Sider (fra-til)489-494
    Antal sider6
    ISSN1403-4948
    DOI
    StatusUdgivet - 2010

    Citer dette

    Tolstrup, J. S., Hansen, J. L., Grønbæk , M., Vogel, U., Tjønneland, A., Joensen, A. M., & Overvad, K. (2010). Alcohol drinking habits, alcohol dehydrogenase genotypes and risk of acute coronary syndrome. Scandinavian Journal of Public Health, 38(5), 489-494. https://doi.org/10.1177/1403494810371248
    Tolstrup, Janne Schurmann ; Hansen, Jane Lindschou ; Grønbæk , Morten ; Vogel, Ulla ; Tjønneland, Anne ; Joensen, Albert Marni ; Overvad, Kim. / Alcohol drinking habits, alcohol dehydrogenase genotypes and risk of acute coronary syndrome. I: Scandinavian Journal of Public Health. 2010 ; Bind 38, Nr. 5. s. 489-494.
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    title = "Alcohol drinking habits, alcohol dehydrogenase genotypes and risk of acute coronary syndrome",
    abstract = "Aims: The risk of myocardial infarction is lower among light-to-moderate drinkers compared with abstainers. Results from some previous studies, but not all, suggest that this association is modified by variations in genes coding for alcohol dehydrogenase (ADH).We aimed to test this hypothesis, including alcohol as both the amount of alcohol and the frequency of drinking. Methods: we conducted a nested case-cohort study within the Danish Diet, Cancer and Health study, including 1,645 men (770 incident cases of acute coronary syndrome from 1993–1997 through 2004 and 875 randomly selected controls). Results: Higher alcohol intake (measured as amount or drinking frequency) was associated with lower risk of acute coronary syndrome; however, there was no evidence that these finding were modified by ADH1B or ADH1C genotypes. Conclusions: The importance of functional variation in alcohol dehydrogenase for the association between alcohol drinking habits and the risk of developing acute coronary syndrome, if any, is very limited.",
    keywords = "Acute coronary syndrome, alcohol, cohort study, genetic epidemiology",
    author = "Tolstrup, {Janne Schurmann} and Hansen, {Jane Lindschou} and Morten Gr{\o}nb{\ae}k and Ulla Vogel and Anne Tj{\o}nneland and Joensen, {Albert Marni} and Kim Overvad",
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    Tolstrup, JS, Hansen, JL, Grønbæk , M, Vogel, U, Tjønneland, A, Joensen, AM & Overvad, K 2010, 'Alcohol drinking habits, alcohol dehydrogenase genotypes and risk of acute coronary syndrome', Scandinavian Journal of Public Health, bind 38, nr. 5, s. 489-494. https://doi.org/10.1177/1403494810371248

    Alcohol drinking habits, alcohol dehydrogenase genotypes and risk of acute coronary syndrome. / Tolstrup, Janne Schurmann; Hansen, Jane Lindschou; Grønbæk , Morten; Vogel, Ulla; Tjønneland, Anne; Joensen, Albert Marni; Overvad, Kim.

    I: Scandinavian Journal of Public Health, Bind 38, Nr. 5, 2010, s. 489-494.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    TY - JOUR

    T1 - Alcohol drinking habits, alcohol dehydrogenase genotypes and risk of acute coronary syndrome

    AU - Tolstrup, Janne Schurmann

    AU - Hansen, Jane Lindschou

    AU - Grønbæk , Morten

    AU - Vogel, Ulla

    AU - Tjønneland, Anne

    AU - Joensen, Albert Marni

    AU - Overvad, Kim

    PY - 2010

    Y1 - 2010

    N2 - Aims: The risk of myocardial infarction is lower among light-to-moderate drinkers compared with abstainers. Results from some previous studies, but not all, suggest that this association is modified by variations in genes coding for alcohol dehydrogenase (ADH).We aimed to test this hypothesis, including alcohol as both the amount of alcohol and the frequency of drinking. Methods: we conducted a nested case-cohort study within the Danish Diet, Cancer and Health study, including 1,645 men (770 incident cases of acute coronary syndrome from 1993–1997 through 2004 and 875 randomly selected controls). Results: Higher alcohol intake (measured as amount or drinking frequency) was associated with lower risk of acute coronary syndrome; however, there was no evidence that these finding were modified by ADH1B or ADH1C genotypes. Conclusions: The importance of functional variation in alcohol dehydrogenase for the association between alcohol drinking habits and the risk of developing acute coronary syndrome, if any, is very limited.

    AB - Aims: The risk of myocardial infarction is lower among light-to-moderate drinkers compared with abstainers. Results from some previous studies, but not all, suggest that this association is modified by variations in genes coding for alcohol dehydrogenase (ADH).We aimed to test this hypothesis, including alcohol as both the amount of alcohol and the frequency of drinking. Methods: we conducted a nested case-cohort study within the Danish Diet, Cancer and Health study, including 1,645 men (770 incident cases of acute coronary syndrome from 1993–1997 through 2004 and 875 randomly selected controls). Results: Higher alcohol intake (measured as amount or drinking frequency) was associated with lower risk of acute coronary syndrome; however, there was no evidence that these finding were modified by ADH1B or ADH1C genotypes. Conclusions: The importance of functional variation in alcohol dehydrogenase for the association between alcohol drinking habits and the risk of developing acute coronary syndrome, if any, is very limited.

    KW - Acute coronary syndrome

    KW - alcohol

    KW - cohort study

    KW - genetic epidemiology

    U2 - 10.1177/1403494810371248

    DO - 10.1177/1403494810371248

    M3 - Journal article

    VL - 38

    SP - 489

    EP - 494

    JO - Scandinavian Journal of Public Health

    JF - Scandinavian Journal of Public Health

    SN - 1403-4948

    IS - 5

    ER -