Alcohol drinking habits, alcohol dehydrogenase genotypes and risk of acute coronary syndrome

Janne Schurmann Tolstrup; Jane Lindschou Hansen; Morten Grønbæk; Ulla Vogel; Anne Tjønneland; Albert Marni Joensen; Kim Overvad

doi:10.1177/1403494810371248

Alcohol drinking habits, alcohol dehydrogenase genotypes and risk of acute coronary syndrome

Janne Schurmann Tolstrup, Jane Lindschou Hansen, Morten Grønbæk , Ulla Vogel, Anne Tjønneland, Albert Marni Joensen, Kim Overvad

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

Aims: The risk of myocardial infarction is lower among light-to-moderate drinkers compared with abstainers. Results from some previous studies, but not all, suggest that this association is modified by variations in genes coding for alcohol dehydrogenase (ADH).We aimed to test this hypothesis, including alcohol as both the amount of alcohol and the frequency of drinking. Methods: we conducted a nested case-cohort study within the Danish Diet, Cancer and Health study, including 1,645 men (770 incident cases of acute coronary syndrome from 1993–1997 through 2004 and 875 randomly selected controls). Results: Higher alcohol intake (measured as amount or drinking frequency) was associated with lower risk of acute coronary syndrome; however, there was no evidence that these finding were modified by ADH1B or ADH1C genotypes.
Conclusions: The importance of functional variation in alcohol dehydrogenase for the association between alcohol drinking habits and the risk of developing acute coronary syndrome, if any, is very limited.

Originalsprog	Engelsk
Tidsskrift	Scandinavian Journal of Public Health
Vol/bind	38
Udgave nummer	5
Sider (fra-til)	489-494
Antal sider	6
ISSN	1403-4948
DOI	https://doi.org/10.1177/1403494810371248
Status	Udgivet - 2010

Link til dokument

10.1177/1403494810371248

Citer dette

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title = "Alcohol drinking habits, alcohol dehydrogenase genotypes and risk of acute coronary syndrome",

abstract = "Aims: The risk of myocardial infarction is lower among light-to-moderate drinkers compared with abstainers. Results from some previous studies, but not all, suggest that this association is modified by variations in genes coding for alcohol dehydrogenase (ADH).We aimed to test this hypothesis, including alcohol as both the amount of alcohol and the frequency of drinking. Methods: we conducted a nested case-cohort study within the Danish Diet, Cancer and Health study, including 1,645 men (770 incident cases of acute coronary syndrome from 1993–1997 through 2004 and 875 randomly selected controls). Results: Higher alcohol intake (measured as amount or drinking frequency) was associated with lower risk of acute coronary syndrome; however, there was no evidence that these finding were modified by ADH1B or ADH1C genotypes. Conclusions: The importance of functional variation in alcohol dehydrogenase for the association between alcohol drinking habits and the risk of developing acute coronary syndrome, if any, is very limited.",

keywords = "Acute coronary syndrome, alcohol, cohort study, genetic epidemiology",

author = "Tolstrup, {Janne Schurmann} and Hansen, {Jane Lindschou} and Morten Gr{\o}nb{\ae}k and Ulla Vogel and Anne Tj{\o}nneland and Joensen, {Albert Marni} and Kim Overvad",

year = "2010",

doi = "10.1177/1403494810371248",

language = "English",

volume = "38",

pages = "489--494",

journal = "Scandinavian Journal of Public Health",

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TY - JOUR

T1 - Alcohol drinking habits, alcohol dehydrogenase genotypes and risk of acute coronary syndrome

AU - Tolstrup, Janne Schurmann

AU - Hansen, Jane Lindschou

AU - Grønbæk , Morten

AU - Vogel, Ulla

AU - Tjønneland, Anne

AU - Joensen, Albert Marni

AU - Overvad, Kim

PY - 2010

Y1 - 2010

N2 - Aims: The risk of myocardial infarction is lower among light-to-moderate drinkers compared with abstainers. Results from some previous studies, but not all, suggest that this association is modified by variations in genes coding for alcohol dehydrogenase (ADH).We aimed to test this hypothesis, including alcohol as both the amount of alcohol and the frequency of drinking. Methods: we conducted a nested case-cohort study within the Danish Diet, Cancer and Health study, including 1,645 men (770 incident cases of acute coronary syndrome from 1993–1997 through 2004 and 875 randomly selected controls). Results: Higher alcohol intake (measured as amount or drinking frequency) was associated with lower risk of acute coronary syndrome; however, there was no evidence that these finding were modified by ADH1B or ADH1C genotypes. Conclusions: The importance of functional variation in alcohol dehydrogenase for the association between alcohol drinking habits and the risk of developing acute coronary syndrome, if any, is very limited.

AB - Aims: The risk of myocardial infarction is lower among light-to-moderate drinkers compared with abstainers. Results from some previous studies, but not all, suggest that this association is modified by variations in genes coding for alcohol dehydrogenase (ADH).We aimed to test this hypothesis, including alcohol as both the amount of alcohol and the frequency of drinking. Methods: we conducted a nested case-cohort study within the Danish Diet, Cancer and Health study, including 1,645 men (770 incident cases of acute coronary syndrome from 1993–1997 through 2004 and 875 randomly selected controls). Results: Higher alcohol intake (measured as amount or drinking frequency) was associated with lower risk of acute coronary syndrome; however, there was no evidence that these finding were modified by ADH1B or ADH1C genotypes. Conclusions: The importance of functional variation in alcohol dehydrogenase for the association between alcohol drinking habits and the risk of developing acute coronary syndrome, if any, is very limited.

KW - Acute coronary syndrome

KW - alcohol

KW - cohort study

KW - genetic epidemiology

U2 - 10.1177/1403494810371248

DO - 10.1177/1403494810371248

M3 - Journal article

SN - 1403-4948

VL - 38

SP - 489

EP - 494

JO - Scandinavian Journal of Public Health

JF - Scandinavian Journal of Public Health

IS - 5

ER -