Absorption and initial metabolism of 75Se-L-selenomethionine: a kinetic model based on dynamic scintigraphic data

Mareile Ruse Große, Lasse Søndergaard, Susanne Ditlevsen, Morten Damgaard, Stefan Fuglsang, Johnny T. Ottesen, Jan Lysgård Madsen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Selenomethionine (SeMet) is an important organic nutritional source of Se, but the uptake and metabolism of SeMet are poorly characterised in humans. Dynamic gamma camera images of the abdominal region were acquired from eight healthy young men after the ingestion of radioactive 75Se-l-SeMet (75Se-SeMet). Scanning started simultaneously to the ingestion of 75Se-SeMet and lasted 120 min. We generated time-activity curves from two-dimensional regions of interest in the stomach, small intestine and liver. During scanning, blood samples were collected at 10-min intervals to generate plasma time-activity curves. A four-compartment model, augmented with a delay between the liver and plasma, was fitted to individual participants' data. The mean rate constant for 75Se-SeMet transport was 2·63 h-1 from the stomach to the small intestine, 13·2 h-1 from the small intestine to the liver, 0·261 h-1 from the liver to the plasma and 0·267 h-1 from the stomach to the plasma. The delay in the liver was 0·714 h. Gamma camera imaging provides data for use in compartmental modelling of 75Se-SeMet absorption and metabolism in humans. In clinical settings, the obtained rate constants and the delay in the liver may be useful variables for quantifying reduced intestinal absorption capacity or liver function.
OriginalsprogEngelsk
TidsskriftBritish Journal of Nutrition
Vol/bind114
Udgave nummer10
Sider (fra-til)1718-1723
ISSN0007-1145
DOI
StatusUdgivet - 28 nov. 2015

Citer dette

Große, Mareile Ruse ; Søndergaard, Lasse ; Ditlevsen, Susanne ; Damgaard, Morten ; Fuglsang, Stefan ; Ottesen, Johnny T. ; Madsen, Jan Lysgård. / Absorption and initial metabolism of 75Se-L-selenomethionine: a kinetic model based on dynamic scintigraphic data. I: British Journal of Nutrition. 2015 ; Bind 114, Nr. 10. s. 1718-1723.
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title = "Absorption and initial metabolism of 75Se-L-selenomethionine: a kinetic model based on dynamic scintigraphic data",
abstract = "Selenomethionine (SeMet) is an important organic nutritional source of Se, but the uptake and metabolism of SeMet are poorly characterised in humans. Dynamic gamma camera images of the abdominal region were acquired from eight healthy young men after the ingestion of radioactive 75Se-l-SeMet (75Se-SeMet). Scanning started simultaneously to the ingestion of 75Se-SeMet and lasted 120 min. We generated time-activity curves from two-dimensional regions of interest in the stomach, small intestine and liver. During scanning, blood samples were collected at 10-min intervals to generate plasma time-activity curves. A four-compartment model, augmented with a delay between the liver and plasma, was fitted to individual participants’ data. The mean rate constant for 75Se-SeMet transport was 2·63 h–1 from the stomach to the small intestine, 13·2 h–1 from the small intestine to the liver, 0·261 h–1 from the liver to the plasma and 0·267 h–1 from the stomach to the plasma. The delay in the liver was 0·714 h. Gamma camera imaging provides data for use in compartmental modelling of 75Se-SeMet absorption and metabolism in humans. In clinical settings, the obtained rate constants and the delay in the liver may be useful variables for quantifying reduced intestinal absorption capacity or liver function",
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Absorption and initial metabolism of 75Se-L-selenomethionine: a kinetic model based on dynamic scintigraphic data. / Große, Mareile Ruse; Søndergaard, Lasse; Ditlevsen, Susanne ; Damgaard, Morten; Fuglsang, Stefan; Ottesen, Johnny T.; Madsen, Jan Lysgård.

I: British Journal of Nutrition, Bind 114, Nr. 10, 28.11.2015, s. 1718-1723.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Absorption and initial metabolism of 75Se-L-selenomethionine: a kinetic model based on dynamic scintigraphic data

AU - Große, Mareile Ruse

AU - Søndergaard, Lasse

AU - Ditlevsen, Susanne

AU - Damgaard, Morten

AU - Fuglsang, Stefan

AU - Ottesen, Johnny T.

AU - Madsen, Jan Lysgård

PY - 2015/11/28

Y1 - 2015/11/28

N2 - Selenomethionine (SeMet) is an important organic nutritional source of Se, but the uptake and metabolism of SeMet are poorly characterised in humans. Dynamic gamma camera images of the abdominal region were acquired from eight healthy young men after the ingestion of radioactive 75Se-l-SeMet (75Se-SeMet). Scanning started simultaneously to the ingestion of 75Se-SeMet and lasted 120 min. We generated time-activity curves from two-dimensional regions of interest in the stomach, small intestine and liver. During scanning, blood samples were collected at 10-min intervals to generate plasma time-activity curves. A four-compartment model, augmented with a delay between the liver and plasma, was fitted to individual participants’ data. The mean rate constant for 75Se-SeMet transport was 2·63 h–1 from the stomach to the small intestine, 13·2 h–1 from the small intestine to the liver, 0·261 h–1 from the liver to the plasma and 0·267 h–1 from the stomach to the plasma. The delay in the liver was 0·714 h. Gamma camera imaging provides data for use in compartmental modelling of 75Se-SeMet absorption and metabolism in humans. In clinical settings, the obtained rate constants and the delay in the liver may be useful variables for quantifying reduced intestinal absorption capacity or liver function

AB - Selenomethionine (SeMet) is an important organic nutritional source of Se, but the uptake and metabolism of SeMet are poorly characterised in humans. Dynamic gamma camera images of the abdominal region were acquired from eight healthy young men after the ingestion of radioactive 75Se-l-SeMet (75Se-SeMet). Scanning started simultaneously to the ingestion of 75Se-SeMet and lasted 120 min. We generated time-activity curves from two-dimensional regions of interest in the stomach, small intestine and liver. During scanning, blood samples were collected at 10-min intervals to generate plasma time-activity curves. A four-compartment model, augmented with a delay between the liver and plasma, was fitted to individual participants’ data. The mean rate constant for 75Se-SeMet transport was 2·63 h–1 from the stomach to the small intestine, 13·2 h–1 from the small intestine to the liver, 0·261 h–1 from the liver to the plasma and 0·267 h–1 from the stomach to the plasma. The delay in the liver was 0·714 h. Gamma camera imaging provides data for use in compartmental modelling of 75Se-SeMet absorption and metabolism in humans. In clinical settings, the obtained rate constants and the delay in the liver may be useful variables for quantifying reduced intestinal absorption capacity or liver function

U2 - 10.1017/S000711451500344X

DO - 10.1017/S000711451500344X

M3 - Journal article

VL - 114

SP - 1718

EP - 1723

JO - British Journal of Nutrition

JF - British Journal of Nutrition

SN - 0007-1145

IS - 10

ER -