Abstract
The aim of the present thesis has been to evaluate a recently
developed short term
in vivo
model, the aberrant crypt foci
bioassay (ACF), for its ability to predict the development of
colo-rectal tumors. Based on the knowledge obtained during the
last decade, it can be stated that no simple connection exists
between occurrence of ACF (neither qualitatively nor quantita-
tively) and later development of tumors. However, the literature
has shown that part of the ACF show morphologic and genetic
features characteristic for the tumorigenic process and a recent
investigation indicate that all ACF belong to the same unity with
basically the same chances for gradual progressing into tumors.
It may be speculated that the progression depends on promo-
tional conditions in the environment.
developed short term
in vivo
model, the aberrant crypt foci
bioassay (ACF), for its ability to predict the development of
colo-rectal tumors. Based on the knowledge obtained during the
last decade, it can be stated that no simple connection exists
between occurrence of ACF (neither qualitatively nor quantita-
tively) and later development of tumors. However, the literature
has shown that part of the ACF show morphologic and genetic
features characteristic for the tumorigenic process and a recent
investigation indicate that all ACF belong to the same unity with
basically the same chances for gradual progressing into tumors.
It may be speculated that the progression depends on promo-
tional conditions in the environment.
| Originalsprog | Engelsk |
|---|
| Forlag | National Food Agency of Denmark |
|---|---|
| Antal sider | 57 |
| Status | Udgivet - 1996 |
Emneord
- Aberrant crypt foci
- ACF
- colo-rectal cancer
- histomorphology