Resumé
developed short term
in vivo
model, the aberrant crypt foci
bioassay (ACF), for its ability to predict the development of
colo-rectal tumors. Based on the knowledge obtained during the
last decade, it can be stated that no simple connection exists
between occurrence of ACF (neither qualitatively nor quantita-
tively) and later development of tumors. However, the literature
has shown that part of the ACF show morphologic and genetic
features characteristic for the tumorigenic process and a recent
investigation indicate that all ACF belong to the same unity with
basically the same chances for gradual progressing into tumors.
It may be speculated that the progression depends on promo-
tional conditions in the environment.
| Originalsprog | Engelsk |
|---|
| Forlag | National Food Agency of Denmark |
|---|---|
| Antal sider | 57 |
| Status | Udgivet - 1996 |
Emneord
- Aberrant crypt foci
- ACF
- colo-rectal cancer
- histomorphology
Citer dette
}
Publikation: Bog/antologi/afhandling/rapport › Ph.d.-afhandling › Forskning
TY - BOOK
T1 - Aberrant crypt foci in the colo-rectal mucosa as reliable markers of tumor development
T2 - with special reference to histomorphological and immunohistochemical characterization of aberrant crypt foci in rats
AU - Thorup, Inger
PY - 1996
Y1 - 1996
N2 - The aim of the present thesis has been to evaluate a recentlydeveloped short termin vivomodel, the aberrant crypt focibioassay (ACF), for its ability to predict the development ofcolo-rectal tumors. Based on the knowledge obtained during thelast decade, it can be stated that no simple connection existsbetween occurrence of ACF (neither qualitatively nor quantita-tively) and later development of tumors. However, the literaturehas shown that part of the ACF show morphologic and geneticfeatures characteristic for the tumorigenic process and a recentinvestigation indicate that all ACF belong to the same unity withbasically the same chances for gradual progressing into tumors.It may be speculated that the progression depends on promo-tional conditions in the environment.
AB - The aim of the present thesis has been to evaluate a recentlydeveloped short termin vivomodel, the aberrant crypt focibioassay (ACF), for its ability to predict the development ofcolo-rectal tumors. Based on the knowledge obtained during thelast decade, it can be stated that no simple connection existsbetween occurrence of ACF (neither qualitatively nor quantita-tively) and later development of tumors. However, the literaturehas shown that part of the ACF show morphologic and geneticfeatures characteristic for the tumorigenic process and a recentinvestigation indicate that all ACF belong to the same unity withbasically the same chances for gradual progressing into tumors.It may be speculated that the progression depends on promo-tional conditions in the environment.
KW - Aberrant crypt foci
KW - ACF
KW - colo-rectal cancer
KW - histomorphology
M3 - Ph.D. thesis
BT - Aberrant crypt foci in the colo-rectal mucosa as reliable markers of tumor development
PB - National Food Agency of Denmark
ER -