Aberrant crypt foci in the colo-rectal mucosa as reliable markers of tumor development

with special reference to histomorphological and immunohistochemical characterization of aberrant crypt foci in rats

Inger Thorup

    Publikation: Bog/antologi/afhandling/rapportPh.d.-afhandlingForskning

    Resumé

    The aim of the present thesis has been to evaluate a recently
    developed short term
    in vivo
    model, the aberrant crypt foci
    bioassay (ACF), for its ability to predict the development of
    colo-rectal tumors. Based on the knowledge obtained during the
    last decade, it can be stated that no simple connection exists
    between occurrence of ACF (neither qualitatively nor quantita-
    tively) and later development of tumors. However, the literature
    has shown that part of the ACF show morphologic and genetic
    features characteristic for the tumorigenic process and a recent
    investigation indicate that all ACF belong to the same unity with
    basically the same chances for gradual progressing into tumors.
    It may be speculated that the progression depends on promo-
    tional conditions in the environment.
    OriginalsprogEngelsk
    ForlagNational Food Agency of Denmark
    Antal sider57
    StatusUdgivet - 1996

    Emneord

    • Aberrant crypt foci
    • ACF
    • colo-rectal cancer
    • histomorphology

    Citer dette

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    title = "Aberrant crypt foci in the colo-rectal mucosa as reliable markers of tumor development: with special reference to histomorphological and immunohistochemical characterization of aberrant crypt foci in rats",
    abstract = "The aim of the present thesis has been to evaluate a recentlydeveloped short termin vivomodel, the aberrant crypt focibioassay (ACF), for its ability to predict the development ofcolo-rectal tumors. Based on the knowledge obtained during thelast decade, it can be stated that no simple connection existsbetween occurrence of ACF (neither qualitatively nor quantita-tively) and later development of tumors. However, the literaturehas shown that part of the ACF show morphologic and geneticfeatures characteristic for the tumorigenic process and a recentinvestigation indicate that all ACF belong to the same unity withbasically the same chances for gradual progressing into tumors.It may be speculated that the progression depends on promo-tional conditions in the environment.",
    keywords = "Aberrant crypt foci, ACF, colo-rectal cancer, histomorphology",
    author = "Inger Thorup",
    year = "1996",
    language = "English",
    publisher = "National Food Agency of Denmark",

    }

    Aberrant crypt foci in the colo-rectal mucosa as reliable markers of tumor development : with special reference to histomorphological and immunohistochemical characterization of aberrant crypt foci in rats. / Thorup, Inger.

    National Food Agency of Denmark, 1996. 57 s.

    Publikation: Bog/antologi/afhandling/rapportPh.d.-afhandlingForskning

    TY - BOOK

    T1 - Aberrant crypt foci in the colo-rectal mucosa as reliable markers of tumor development

    T2 - with special reference to histomorphological and immunohistochemical characterization of aberrant crypt foci in rats

    AU - Thorup, Inger

    PY - 1996

    Y1 - 1996

    N2 - The aim of the present thesis has been to evaluate a recentlydeveloped short termin vivomodel, the aberrant crypt focibioassay (ACF), for its ability to predict the development ofcolo-rectal tumors. Based on the knowledge obtained during thelast decade, it can be stated that no simple connection existsbetween occurrence of ACF (neither qualitatively nor quantita-tively) and later development of tumors. However, the literaturehas shown that part of the ACF show morphologic and geneticfeatures characteristic for the tumorigenic process and a recentinvestigation indicate that all ACF belong to the same unity withbasically the same chances for gradual progressing into tumors.It may be speculated that the progression depends on promo-tional conditions in the environment.

    AB - The aim of the present thesis has been to evaluate a recentlydeveloped short termin vivomodel, the aberrant crypt focibioassay (ACF), for its ability to predict the development ofcolo-rectal tumors. Based on the knowledge obtained during thelast decade, it can be stated that no simple connection existsbetween occurrence of ACF (neither qualitatively nor quantita-tively) and later development of tumors. However, the literaturehas shown that part of the ACF show morphologic and geneticfeatures characteristic for the tumorigenic process and a recentinvestigation indicate that all ACF belong to the same unity withbasically the same chances for gradual progressing into tumors.It may be speculated that the progression depends on promo-tional conditions in the environment.

    KW - Aberrant crypt foci

    KW - ACF

    KW - colo-rectal cancer

    KW - histomorphology

    M3 - Ph.D. thesis

    BT - Aberrant crypt foci in the colo-rectal mucosa as reliable markers of tumor development

    PB - National Food Agency of Denmark

    ER -