Abstract
A total synthesis of phomactin A (1) based on a Cr(II)/Ni(II) macrocyclisation from the aldehyde vinyl iodide 11, leading to 12, followed by elaboration of the epoxyketone 16, which then undergoes spontaneous pyran-hemiacetal formation on deprotection, is described.
Graphical abstract: A total synthesis of phomactin A
Graphical abstract: A total synthesis of phomactin A
Originalsprog | Engelsk |
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Tidsskrift | Chemical Communications |
Udgave nummer | 16 |
Sider (fra-til) | 1736-1737 |
Antal sider | 2 |
ISSN | 1359-7345 |
DOI | |
Status | Udgivet - 2002 |
Udgivet eksternt | Ja |