A study of salt effects on the complexation between beta-cyclodextrins and bile salts based on the Hofmeister series

Rene Holm, Pitchayanun Somprasirt, Peter Westh, Huiling Mu, Jens Christian Sidney Schönbeck

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    Resumé

    The Hofmeister series is the ranking of ions according to their ability to strengthen (kosmotropic ions) or weaken (chaotropic ions) hydrophobic interactions. Such ions are therefore expected to affect the strength of cyclodextrin (CD) inclusion complexes and may thereby affect the release of CD bound drug molecules. The influence of Hofmeister ions on the binding constants of complexes between CDs (β-CD and hydroxypropylated β-CD) and bile salts (glycocholate and glycochenodeoxycholate) were examined by isothermal titration calorimetry. The chaotropic anions tended to weaken these inclusion complexes. Conversely, kosmotropic ions increased the binding strength and this effect scaled with the buried hydrophobic surface area. Both effects are relatively weak at physiological ion concentrations and may be neglected for most pharmaceutical purposes
    OriginalsprogEngelsk
    TidsskriftJournal of Inclusion Phenomena and Macrocyclic Chemistry
    Vol/bind80
    Udgave nummer3-4
    Sider (fra-til)243-251
    ISSN1388-3127
    DOI
    StatusUdgivet - 2014

    Citer dette

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    title = "A study of salt effects on the complexation between beta-cyclodextrins and bile salts based on the Hofmeister series",
    abstract = "The Hofmeister series is the ranking of ions according to their ability to strengthen (kosmotropic ions) or weaken (chaotropic ions) hydrophobic interactions. Such ions are therefore expected to affect the strength of cyclodextrin (CD) inclusion complexes and may thereby affect the release of CD bound drug molecules. The influence of Hofmeister ions on the binding constants of complexes between CDs (β-CD and hydroxypropylated β-CD) and bile salts (glycocholate and glycochenodeoxycholate) were examined by isothermal titration calorimetry. The chaotropic anions tended to weaken these inclusion complexes. Conversely, kosmotropic ions increased the binding strength and this effect scaled with the buried hydrophobic surface area. Both effects are relatively weak at physiological ion concentrations and may be neglected for most pharmaceutical purposes",
    author = "Rene Holm and Pitchayanun Somprasirt and Peter Westh and Huiling Mu and Sch{\"o}nbeck, {Jens Christian Sidney}",
    year = "2014",
    doi = "10.1007/s10847-014-0383-9",
    language = "English",
    volume = "80",
    pages = "243--251",
    journal = "Journal of Inclusion Phenomena and Macrocyclic Chemistry",
    issn = "1388-3127",
    publisher = "Springer Netherlands",
    number = "3-4",

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    A study of salt effects on the complexation between beta-cyclodextrins and bile salts based on the Hofmeister series. / Holm, Rene; Somprasirt, Pitchayanun; Westh, Peter; Mu, Huiling; Schönbeck, Jens Christian Sidney.

    I: Journal of Inclusion Phenomena and Macrocyclic Chemistry, Bind 80, Nr. 3-4, 2014, s. 243-251.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    TY - JOUR

    T1 - A study of salt effects on the complexation between beta-cyclodextrins and bile salts based on the Hofmeister series

    AU - Holm, Rene

    AU - Somprasirt, Pitchayanun

    AU - Westh, Peter

    AU - Mu, Huiling

    AU - Schönbeck, Jens Christian Sidney

    PY - 2014

    Y1 - 2014

    N2 - The Hofmeister series is the ranking of ions according to their ability to strengthen (kosmotropic ions) or weaken (chaotropic ions) hydrophobic interactions. Such ions are therefore expected to affect the strength of cyclodextrin (CD) inclusion complexes and may thereby affect the release of CD bound drug molecules. The influence of Hofmeister ions on the binding constants of complexes between CDs (β-CD and hydroxypropylated β-CD) and bile salts (glycocholate and glycochenodeoxycholate) were examined by isothermal titration calorimetry. The chaotropic anions tended to weaken these inclusion complexes. Conversely, kosmotropic ions increased the binding strength and this effect scaled with the buried hydrophobic surface area. Both effects are relatively weak at physiological ion concentrations and may be neglected for most pharmaceutical purposes

    AB - The Hofmeister series is the ranking of ions according to their ability to strengthen (kosmotropic ions) or weaken (chaotropic ions) hydrophobic interactions. Such ions are therefore expected to affect the strength of cyclodextrin (CD) inclusion complexes and may thereby affect the release of CD bound drug molecules. The influence of Hofmeister ions on the binding constants of complexes between CDs (β-CD and hydroxypropylated β-CD) and bile salts (glycocholate and glycochenodeoxycholate) were examined by isothermal titration calorimetry. The chaotropic anions tended to weaken these inclusion complexes. Conversely, kosmotropic ions increased the binding strength and this effect scaled with the buried hydrophobic surface area. Both effects are relatively weak at physiological ion concentrations and may be neglected for most pharmaceutical purposes

    U2 - 10.1007/s10847-014-0383-9

    DO - 10.1007/s10847-014-0383-9

    M3 - Journal article

    VL - 80

    SP - 243

    EP - 251

    JO - Journal of Inclusion Phenomena and Macrocyclic Chemistry

    JF - Journal of Inclusion Phenomena and Macrocyclic Chemistry

    SN - 1388-3127

    IS - 3-4

    ER -