A role for the weak DnaA binding sites in bacterial replication origins

Godefroid Charbon, Anders Løbner-Olesen

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

    Resumé

    DnaA initiates the chromosomal DNA replication in nearly all bacteria, and replication origins are characterized by binding sites for the DnaA protein (DnaA-boxes) along with an ‘AT-rich’ region. However, great variation in number, spatial organization and specificity of DnaA-boxes is observed between species. In the study by Taylor et al. (2011), new and unexpectedly weak DnaA-boxes were identified within the Caulobacter crescentus origin of replication (Cori). The position of weak and stronger DnaA-boxes follows a pattern seen in Escherichia coli oriC. This raises the possibility that bacterial origins might be more alike than previously thought.
    OriginalsprogEngelsk
    TidsskriftMolecular Microbiology
    Vol/bind82
    Udgave nummer2
    Sider (fra-til)272-4
    ISSN0950-382X
    DOI
    StatusUdgivet - okt. 2011

    Citer dette

    Charbon, Godefroid ; Løbner-Olesen, Anders. / A role for the weak DnaA binding sites in bacterial replication origins. I: Molecular Microbiology. 2011 ; Bind 82, Nr. 2. s. 272-4.
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    abstract = "DnaA initiates the chromosomal DNA replication in nearly all bacteria, and replication origins are characterized by binding sites for the DnaA protein (DnaA-boxes) along with an ‘AT-rich’ region. However, great variation in number, spatial organization and specificity of DnaA-boxes is observed between species. In the study by Taylor et al. (2011), new and unexpectedly weak DnaA-boxes were identified within the Caulobacter crescentus origin of replication (Cori). The position of weak and stronger DnaA-boxes follows a pattern seen in Escherichia coli oriC. This raises the possibility that bacterial origins might be more alike than previously thought.",
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    A role for the weak DnaA binding sites in bacterial replication origins. / Charbon, Godefroid; Løbner-Olesen, Anders.

    I: Molecular Microbiology, Bind 82, Nr. 2, 10.2011, s. 272-4.

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

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    AU - Løbner-Olesen, Anders

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    N2 - DnaA initiates the chromosomal DNA replication in nearly all bacteria, and replication origins are characterized by binding sites for the DnaA protein (DnaA-boxes) along with an ‘AT-rich’ region. However, great variation in number, spatial organization and specificity of DnaA-boxes is observed between species. In the study by Taylor et al. (2011), new and unexpectedly weak DnaA-boxes were identified within the Caulobacter crescentus origin of replication (Cori). The position of weak and stronger DnaA-boxes follows a pattern seen in Escherichia coli oriC. This raises the possibility that bacterial origins might be more alike than previously thought.

    AB - DnaA initiates the chromosomal DNA replication in nearly all bacteria, and replication origins are characterized by binding sites for the DnaA protein (DnaA-boxes) along with an ‘AT-rich’ region. However, great variation in number, spatial organization and specificity of DnaA-boxes is observed between species. In the study by Taylor et al. (2011), new and unexpectedly weak DnaA-boxes were identified within the Caulobacter crescentus origin of replication (Cori). The position of weak and stronger DnaA-boxes follows a pattern seen in Escherichia coli oriC. This raises the possibility that bacterial origins might be more alike than previously thought.

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