A multisubstrate deoxyribonucleoside kinase from plants

Anders R. Clausen; Lenart Girandon; Wolfgang Knecht; Sabeen Survery; Eric Andreasson; Birgitte Munch-Petersen; Jure Piskur

doi:10.1093/nass/nrn248

A multisubstrate deoxyribonucleoside kinase from plants

Anders R. Clausen
, Lenart Girandon
, Wolfgang Knecht
, Sabeen Survery
, Eric Andreasson
, Birgitte Munch-Petersen
, Jure Piskur

Publikation: Bidrag til tidsskrift › Konferenceartikel › Forskning

2 Citationer (Scopus)

Abstract

Deoxyribonucleoside kinases catalyze the rate limiting step during the salvage of deoxyribonucleosides and convert them into the corresponding monophosphate compounds. We have identified and characterized a unique multisubstrate deoxyribonucleoside kinase from plants. The phylogenetic relationship and biochemical properties suggest that this deoxyribonucleoside kinase represents a living fossil resembling the progenitor of the modern animal deoxycytidine, deoxyguanosine and thymidine 2 kinases. The broad substrate specificity makes this enzyme an interesting candidate to be evaluated as a suicide gene in anti-cancer therapy.

Originalsprog	Engelsk
Bogserie	Nucleic Acids Symposium Series
Sider (fra-til)	489-490
Antal sider	2
ISSN	0261-3166
DOI	https://doi.org/10.1093/nass/nrn248
Status	Udgivet - 2008
Begivenhed	Joint symposium of the 18th international roundtable on nucleosides, nucleotides and nucleic acids and the 35th international symposium on nucleic acids chemistry - Tokyo, Japan Varighed: 8 sep. 2008 → 12 sep. 2008

Konference

Konference	Joint symposium of the 18th international roundtable on nucleosides, nucleotides and nucleic acids and the 35th international symposium on nucleic acids chemistry
Land/Område	Japan
By	Tokyo
Periode	08/09/2008 → 12/09/2008

Bibliografisk note

Volumne: 52

Emneord

plants

Adgang til dokumentet

10.1093/nass/nrn248

KB link

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Citationsformater

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title = "A multisubstrate deoxyribonucleoside kinase from plants",

abstract = "Deoxyribonucleoside kinases catalyze the rate limiting step during the salvage of deoxyribonucleosides and convert them into the corresponding monophosphate compounds. We have identified and characterized a unique multisubstrate deoxyribonucleoside kinase from plants. The phylogenetic relationship and biochemical properties suggest that this deoxyribonucleoside kinase represents a living fossil resembling the progenitor of the modern animal deoxycytidine, deoxyguanosine and thymidine 2 kinases. The broad substrate specificity makes this enzyme an interesting candidate to be evaluated as a suicide gene in anti-cancer therapy.",

keywords = "plants, deoxyribonucleoside kinase, Arabidopsis",

author = "Clausen, \{Anders R.\} and Lenart Girandon and Wolfgang Knecht and Sabeen Survery and Eric Andreasson and Birgitte Munch-Petersen and Jure Piskur",

note = "Volumne: 52; Joint symposium of the 18th international roundtable on nucleosides, nucleotides and nucleic acids and the 35th international symposium on nucleic acids chemistry ; Conference date: 08-09-2008 Through 12-09-2008",

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doi = "10.1093/nass/nrn248",

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journal = "Nucleic Acids Symposium Series",

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T1 - A multisubstrate deoxyribonucleoside kinase from plants

AU - Clausen, Anders R.

AU - Girandon, Lenart

AU - Knecht, Wolfgang

AU - Survery, Sabeen

AU - Andreasson, Eric

AU - Munch-Petersen, Birgitte

AU - Piskur, Jure

N1 - Volumne: 52

PY - 2008

Y1 - 2008

N2 - Deoxyribonucleoside kinases catalyze the rate limiting step during the salvage of deoxyribonucleosides and convert them into the corresponding monophosphate compounds. We have identified and characterized a unique multisubstrate deoxyribonucleoside kinase from plants. The phylogenetic relationship and biochemical properties suggest that this deoxyribonucleoside kinase represents a living fossil resembling the progenitor of the modern animal deoxycytidine, deoxyguanosine and thymidine 2 kinases. The broad substrate specificity makes this enzyme an interesting candidate to be evaluated as a suicide gene in anti-cancer therapy.

AB - Deoxyribonucleoside kinases catalyze the rate limiting step during the salvage of deoxyribonucleosides and convert them into the corresponding monophosphate compounds. We have identified and characterized a unique multisubstrate deoxyribonucleoside kinase from plants. The phylogenetic relationship and biochemical properties suggest that this deoxyribonucleoside kinase represents a living fossil resembling the progenitor of the modern animal deoxycytidine, deoxyguanosine and thymidine 2 kinases. The broad substrate specificity makes this enzyme an interesting candidate to be evaluated as a suicide gene in anti-cancer therapy.

KW - plants

KW - deoxyribonucleoside kinase

KW - Arabidopsis

U2 - 10.1093/nass/nrn248

DO - 10.1093/nass/nrn248

M3 - Conference article

SN - 0261-3166

SP - 489

EP - 490

JO - Nucleic Acids Symposium Series

JF - Nucleic Acids Symposium Series

T2 - Joint symposium of the 18th international roundtable on nucleosides, nucleotides and nucleic acids and the 35th international symposium on nucleic acids chemistry

Y2 - 8 September 2008 through 12 September 2008

ER -