A multisubstrate deoxyribonucleoside kinase from plants

Anders R. Clausen, Lenart Girandon, Wolfgang Knecht, Sabeen Survery, Eric Andreasson, Birgitte Munch-Petersen, Jure Piskur

    Publikation: Bidrag til tidsskriftKonferenceartikelForskning

    Resumé

    Deoxyribonucleoside kinases catalyze the rate limiting step during the salvage of deoxyribonucleosides and convert them into the corresponding monophosphate compounds. We have identified and characterized a unique multisubstrate deoxyribonucleoside kinase from plants. The phylogenetic relationship and biochemical properties suggest that this deoxyribonucleoside kinase represents a living fossil resembling the progenitor of the modern animal deoxycytidine, deoxyguanosine and thymidine 2 kinases. The broad substrate specificity makes this enzyme an interesting candidate to be evaluated as a suicide gene in anti-cancer therapy.
    OriginalsprogEngelsk
    BogserieNucleic Acids Symposium Series
    Sider (fra-til)489-490
    Antal sider2
    ISSN0261-3166
    DOI
    StatusUdgivet - 2008
    BegivenhedJoint symposium of the 18th international roundtable on nucleosides, nucleotides and nucleic acids and the 35th international symposium on nucleic acids chemistry - Tokyo, Japan
    Varighed: 8 sep. 200812 sep. 2008

    Konference

    KonferenceJoint symposium of the 18th international roundtable on nucleosides, nucleotides and nucleic acids and the 35th international symposium on nucleic acids chemistry
    LandJapan
    ByTokyo
    Periode08/09/200812/09/2008

    Bibliografisk note

    Volumne: 52

    Emneord

    • plants

    Citer dette

    Clausen, A. R., Girandon, L., Knecht, W., Survery, S., Andreasson, E., Munch-Petersen, B., & Piskur, J. (2008). A multisubstrate deoxyribonucleoside kinase from plants. Nucleic Acids Symposium Series, 489-490. https://doi.org/10.1093/nass/nrn248
    Clausen, Anders R. ; Girandon, Lenart ; Knecht, Wolfgang ; Survery, Sabeen ; Andreasson, Eric ; Munch-Petersen, Birgitte ; Piskur, Jure. / A multisubstrate deoxyribonucleoside kinase from plants. I: Nucleic Acids Symposium Series. 2008 ; s. 489-490.
    @inproceedings{2b2d25b0dcc511dd87fb000ea68e967b,
    title = "A multisubstrate deoxyribonucleoside kinase from plants",
    abstract = "Deoxyribonucleoside kinases catalyze the rate limiting step during the salvage of deoxyribonucleosides and convert them into the corresponding monophosphate compounds. We have identified and characterized a unique multisubstrate deoxyribonucleoside kinase from plants. The phylogenetic relationship and biochemical properties suggest that this deoxyribonucleoside kinase represents a living fossil resembling the progenitor of the modern animal deoxycytidine, deoxyguanosine and thymidine 2 kinases. The broad substrate specificity makes this enzyme an interesting candidate to be evaluated as a suicide gene in anti-cancer therapy.",
    keywords = "plants, deoxyribonucleoside kinase, Arabidopsis",
    author = "Clausen, {Anders R.} and Lenart Girandon and Wolfgang Knecht and Sabeen Survery and Eric Andreasson and Birgitte Munch-Petersen and Jure Piskur",
    note = "Volumne: 52",
    year = "2008",
    doi = "10.1093/nass/nrn248",
    language = "English",
    pages = "489--490",
    journal = "Nucleic Acids Symposium Series",
    issn = "0261-3166",
    publisher = "Oxford University Press",

    }

    Clausen, AR, Girandon, L, Knecht, W, Survery, S, Andreasson, E, Munch-Petersen, B & Piskur, J 2008, 'A multisubstrate deoxyribonucleoside kinase from plants', Nucleic Acids Symposium Series, s. 489-490. https://doi.org/10.1093/nass/nrn248

    A multisubstrate deoxyribonucleoside kinase from plants. / Clausen, Anders R.; Girandon, Lenart; Knecht, Wolfgang; Survery, Sabeen; Andreasson, Eric; Munch-Petersen, Birgitte; Piskur, Jure.

    I: Nucleic Acids Symposium Series, 2008, s. 489-490.

    Publikation: Bidrag til tidsskriftKonferenceartikelForskning

    TY - GEN

    T1 - A multisubstrate deoxyribonucleoside kinase from plants

    AU - Clausen, Anders R.

    AU - Girandon, Lenart

    AU - Knecht, Wolfgang

    AU - Survery, Sabeen

    AU - Andreasson, Eric

    AU - Munch-Petersen, Birgitte

    AU - Piskur, Jure

    N1 - Volumne: 52

    PY - 2008

    Y1 - 2008

    N2 - Deoxyribonucleoside kinases catalyze the rate limiting step during the salvage of deoxyribonucleosides and convert them into the corresponding monophosphate compounds. We have identified and characterized a unique multisubstrate deoxyribonucleoside kinase from plants. The phylogenetic relationship and biochemical properties suggest that this deoxyribonucleoside kinase represents a living fossil resembling the progenitor of the modern animal deoxycytidine, deoxyguanosine and thymidine 2 kinases. The broad substrate specificity makes this enzyme an interesting candidate to be evaluated as a suicide gene in anti-cancer therapy.

    AB - Deoxyribonucleoside kinases catalyze the rate limiting step during the salvage of deoxyribonucleosides and convert them into the corresponding monophosphate compounds. We have identified and characterized a unique multisubstrate deoxyribonucleoside kinase from plants. The phylogenetic relationship and biochemical properties suggest that this deoxyribonucleoside kinase represents a living fossil resembling the progenitor of the modern animal deoxycytidine, deoxyguanosine and thymidine 2 kinases. The broad substrate specificity makes this enzyme an interesting candidate to be evaluated as a suicide gene in anti-cancer therapy.

    KW - plants

    KW - deoxyribonucleoside kinase

    KW - Arabidopsis

    U2 - 10.1093/nass/nrn248

    DO - 10.1093/nass/nrn248

    M3 - Conference article

    SP - 489

    EP - 490

    JO - Nucleic Acids Symposium Series

    JF - Nucleic Acids Symposium Series

    SN - 0261-3166

    ER -