Deoxyribonucleoside kinases catalyze the rate limiting step during the salvage of deoxyribonucleosides and convert them into the corresponding monophosphate compounds. We have identified and characterized a unique multisubstrate deoxyribonucleoside kinase from plants. The phylogenetic relationship and biochemical properties suggest that this deoxyribonucleoside kinase represents a living fossil resembling the progenitor of the modern animal deoxycytidine, deoxyguanosine and thymidine 2 kinases. The broad substrate specificity makes this enzyme an interesting candidate to be evaluated as a suicide gene in anti-cancer therapy.
|Bogserie||Nucleic Acids Symposium Series|
|Status||Udgivet - 2008|
|Begivenhed||Joint symposium of the 18th international roundtable on nucleosides, nucleotides and nucleic acids and the 35th international symposium on nucleic acids chemistry - Tokyo, Japan|
Varighed: 8 sep. 2008 → 12 sep. 2008
|Konference||Joint symposium of the 18th international roundtable on nucleosides, nucleotides and nucleic acids and the 35th international symposium on nucleic acids chemistry|
|Periode||08/09/2008 → 12/09/2008|
Bibliografisk noteVolumne: 52