A multisubstrate deoxyribonucleoside kinase from plants

Anders R. Clausen; Lenart Girandon; Wolfgang Knecht; Sabeen Survery; Eric Andreasson; Birgitte Munch-Petersen; Jure Piskur

doi:10.1093/nass/nrn248

A multisubstrate deoxyribonucleoside kinase from plants

Anders R. Clausen, Lenart Girandon, Wolfgang Knecht, Sabeen Survery, Eric Andreasson, Birgitte Munch-Petersen, Jure Piskur

Publikation: Bidrag til tidsskrift › Konferenceartikel › Forskning

Abstract

Deoxyribonucleoside kinases catalyze the rate limiting step during the salvage of deoxyribonucleosides and convert them into the corresponding monophosphate compounds. We have identified and characterized a unique multisubstrate deoxyribonucleoside kinase from plants. The phylogenetic relationship and biochemical properties suggest that this deoxyribonucleoside kinase represents a living fossil resembling the progenitor of the modern animal deoxycytidine, deoxyguanosine and thymidine 2 kinases. The broad substrate specificity makes this enzyme an interesting candidate to be evaluated as a suicide gene in anti-cancer therapy.

Originalsprog	Engelsk
Bogserie	Nucleic Acids Symposium Series
Sider (fra-til)	489-490
Antal sider	2
ISSN	0261-3166
DOI	https://doi.org/10.1093/nass/nrn248
Status	Udgivet - 2008
Begivenhed	Joint symposium of the 18th international roundtable on nucleosides, nucleotides and nucleic acids and the 35th international symposium on nucleic acids chemistry - Tokyo, Japan Varighed: 8 sep. 2008 → 12 sep. 2008

Konference

Konference	Joint symposium of the 18th international roundtable on nucleosides, nucleotides and nucleic acids and the 35th international symposium on nucleic acids chemistry
Land/Område	Japan
By	Tokyo
Periode	08/09/2008 → 12/09/2008

Bibliografisk note

Volumne: 52

Emneord

plants

Link til dokument

10.1093/nass/nrn248

Citer dette

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abstract = "Deoxyribonucleoside kinases catalyze the rate limiting step during the salvage of deoxyribonucleosides and convert them into the corresponding monophosphate compounds. We have identified and characterized a unique multisubstrate deoxyribonucleoside kinase from plants. The phylogenetic relationship and biochemical properties suggest that this deoxyribonucleoside kinase represents a living fossil resembling the progenitor of the modern animal deoxycytidine, deoxyguanosine and thymidine 2 kinases. The broad substrate specificity makes this enzyme an interesting candidate to be evaluated as a suicide gene in anti-cancer therapy.",

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AU - Clausen, Anders R.

AU - Girandon, Lenart

AU - Knecht, Wolfgang

AU - Survery, Sabeen

AU - Andreasson, Eric

AU - Munch-Petersen, Birgitte

AU - Piskur, Jure

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PY - 2008

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N2 - Deoxyribonucleoside kinases catalyze the rate limiting step during the salvage of deoxyribonucleosides and convert them into the corresponding monophosphate compounds. We have identified and characterized a unique multisubstrate deoxyribonucleoside kinase from plants. The phylogenetic relationship and biochemical properties suggest that this deoxyribonucleoside kinase represents a living fossil resembling the progenitor of the modern animal deoxycytidine, deoxyguanosine and thymidine 2 kinases. The broad substrate specificity makes this enzyme an interesting candidate to be evaluated as a suicide gene in anti-cancer therapy.

AB - Deoxyribonucleoside kinases catalyze the rate limiting step during the salvage of deoxyribonucleosides and convert them into the corresponding monophosphate compounds. We have identified and characterized a unique multisubstrate deoxyribonucleoside kinase from plants. The phylogenetic relationship and biochemical properties suggest that this deoxyribonucleoside kinase represents a living fossil resembling the progenitor of the modern animal deoxycytidine, deoxyguanosine and thymidine 2 kinases. The broad substrate specificity makes this enzyme an interesting candidate to be evaluated as a suicide gene in anti-cancer therapy.

KW - plants

KW - deoxyribonucleoside kinase

KW - Arabidopsis

U2 - 10.1093/nass/nrn248

DO - 10.1093/nass/nrn248

M3 - Conference article

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SP - 489

EP - 490

JO - Nucleic Acids Symposium Series

JF - Nucleic Acids Symposium Series

T2 - Joint symposium of the 18th international roundtable on nucleosides, nucleotides and nucleic acids and the 35th international symposium on nucleic acids chemistry

Y2 - 8 September 2008 through 12 September 2008

ER -