A multisubstrate deoxyribonucleoside kinase from plants

Anders R. Clausen, Lenart Girandon, Wolfgang Knecht, Sabeen Survery, Eric Andreasson, Birgitte Munch-Petersen, Jure Piskur

    Publikation: Bidrag til tidsskriftKonferenceartikelForskning

    Abstract

    Deoxyribonucleoside kinases catalyze the rate limiting step during the salvage of deoxyribonucleosides and convert them into the corresponding monophosphate compounds. We have identified and characterized a unique multisubstrate deoxyribonucleoside kinase from plants. The phylogenetic relationship and biochemical properties suggest that this deoxyribonucleoside kinase represents a living fossil resembling the progenitor of the modern animal deoxycytidine, deoxyguanosine and thymidine 2 kinases. The broad substrate specificity makes this enzyme an interesting candidate to be evaluated as a suicide gene in anti-cancer therapy.
    OriginalsprogEngelsk
    BogserieNucleic Acids Symposium Series
    Sider (fra-til)489-490
    Antal sider2
    ISSN0261-3166
    DOI
    StatusUdgivet - 2008
    BegivenhedJoint symposium of the 18th international roundtable on nucleosides, nucleotides and nucleic acids and the 35th international symposium on nucleic acids chemistry - Tokyo, Japan
    Varighed: 8 sep. 200812 sep. 2008

    Konference

    KonferenceJoint symposium of the 18th international roundtable on nucleosides, nucleotides and nucleic acids and the 35th international symposium on nucleic acids chemistry
    LandJapan
    ByTokyo
    Periode08/09/200812/09/2008

    Bibliografisk note

    Volumne: 52

    Emneord

    • plants

    Citer dette

    Clausen, A. R., Girandon, L., Knecht, W., Survery, S., Andreasson, E., Munch-Petersen, B., & Piskur, J. (2008). A multisubstrate deoxyribonucleoside kinase from plants. Nucleic Acids Symposium Series, 489-490. https://doi.org/10.1093/nass/nrn248