_ The mitochondrial enzyme thymidine kinase 2 (TK2) phosphorylates deoxythymidine (dT) and deoxycytidine (dC) to form dTMP and dCMP, which in cells rapidly become the negative-feedback end-products dTTP and dCTP. TK2 kinetic activity exhibits Hill coefficients of ∼0.5 (apparent negative cooperativity) for dT and ∼1 for dC. We present a mathematical model of TK2 activity that is applicable if TK2 exists as two monomer forms in equilibrium.
- thymidin kinase 2
- Mathematical model
Radivoyevitch, T., Munch-Petersen, B., Wang, L., & Eriksson, S. (2011). A mathematical model of human thymidine kinase 2 activity. Nucleosides, Nucleotides and Nucleic Acids, 30(3), 203-209. https://doi.org/10.1080/15257770.2011.563765