A mathematical model of human thymidine kinase 2 activity

Tom Radivoyevitch, Birgitte Munch-Petersen, Liya Wang, Staffan Eriksson

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    Resumé

    _ The mitochondrial enzyme thymidine kinase 2 (TK2) phosphorylates deoxythymidine (dT) and deoxycytidine (dC) to form dTMP and dCMP, which in cells rapidly become the negative-feedback end-products dTTP and dCTP. TK2 kinetic activity exhibits Hill coefficients of ∼0.5 (apparent negative cooperativity) for dT and ∼1 for dC. We present a mathematical model of TK2 activity that is applicable if TK2 exists as two monomer forms in equilibrium.
    OriginalsprogEngelsk
    TidsskriftNucleosides, Nucleotides and Nucleic Acids
    Vol/bind30
    Udgave nummer3
    Sider (fra-til)203-209
    Antal sider7
    ISSN1525-7770
    DOI
    StatusUdgivet - 2011

    Emneord

    • thymidin kinase 2
    • Mathematical model

    Citer dette

    Radivoyevitch, Tom ; Munch-Petersen, Birgitte ; Wang, Liya ; Eriksson, Staffan. / A mathematical model of human thymidine kinase 2 activity. I: Nucleosides, Nucleotides and Nucleic Acids. 2011 ; Bind 30, Nr. 3. s. 203-209.
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    title = "A mathematical model of human thymidine kinase 2 activity",
    abstract = "_ The mitochondrial enzyme thymidine kinase 2 (TK2) phosphorylates deoxythymidine (dT) and deoxycytidine (dC) to form dTMP and dCMP, which in cells rapidly become the negative-feedback end-products dTTP and dCTP. TK2 kinetic activity exhibits Hill coefficients of ∼0.5 (apparent negative cooperativity) for dT and ∼1 for dC. We present a mathematical model of TK2 activity that is applicable if TK2 exists as two monomer forms in equilibrium.",
    keywords = "thymidin kinase 2, Mathematical model",
    author = "Tom Radivoyevitch and Birgitte Munch-Petersen and Liya Wang and Staffan Eriksson",
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    A mathematical model of human thymidine kinase 2 activity. / Radivoyevitch, Tom; Munch-Petersen, Birgitte; Wang, Liya; Eriksson, Staffan.

    I: Nucleosides, Nucleotides and Nucleic Acids, Bind 30, Nr. 3, 2011, s. 203-209.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    TY - JOUR

    T1 - A mathematical model of human thymidine kinase 2 activity

    AU - Radivoyevitch, Tom

    AU - Munch-Petersen, Birgitte

    AU - Wang, Liya

    AU - Eriksson, Staffan

    PY - 2011

    Y1 - 2011

    N2 - _ The mitochondrial enzyme thymidine kinase 2 (TK2) phosphorylates deoxythymidine (dT) and deoxycytidine (dC) to form dTMP and dCMP, which in cells rapidly become the negative-feedback end-products dTTP and dCTP. TK2 kinetic activity exhibits Hill coefficients of ∼0.5 (apparent negative cooperativity) for dT and ∼1 for dC. We present a mathematical model of TK2 activity that is applicable if TK2 exists as two monomer forms in equilibrium.

    AB - _ The mitochondrial enzyme thymidine kinase 2 (TK2) phosphorylates deoxythymidine (dT) and deoxycytidine (dC) to form dTMP and dCMP, which in cells rapidly become the negative-feedback end-products dTTP and dCTP. TK2 kinetic activity exhibits Hill coefficients of ∼0.5 (apparent negative cooperativity) for dT and ∼1 for dC. We present a mathematical model of TK2 activity that is applicable if TK2 exists as two monomer forms in equilibrium.

    KW - thymidin kinase 2

    KW - Mathematical model

    U2 - 10.1080/15257770.2011.563765

    DO - 10.1080/15257770.2011.563765

    M3 - Journal article

    VL - 30

    SP - 203

    EP - 209

    JO - Nucleosides, Nucleotides and Nucleic Acids

    JF - Nucleosides, Nucleotides and Nucleic Acids

    SN - 1525-7770

    IS - 3

    ER -