A mathematical model of human thymidine kinase 2 activity

Tom Radivoyevitch; Birgitte Munch-Petersen; Liya Wang; Staffan Eriksson

doi:10.1080/15257770.2011.563765

A mathematical model of human thymidine kinase 2 activity

Tom Radivoyevitch, Birgitte Munch-Petersen, Liya Wang, Staffan Eriksson

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

_ The mitochondrial enzyme thymidine kinase 2 (TK2) phosphorylates deoxythymidine (dT) and deoxycytidine (dC) to form dTMP and dCMP, which in cells rapidly become the negative-feedback end-products dTTP and dCTP. TK2 kinetic activity exhibits Hill coefficients of ∼0.5 (apparent negative cooperativity) for dT and ∼1 for dC. We present a mathematical model of TK2 activity that is applicable if TK2 exists as two monomer forms in equilibrium.

Originalsprog	Engelsk
Tidsskrift	Nucleosides, Nucleotides and Nucleic Acids
Vol/bind	30
Udgave nummer	3
Sider (fra-til)	203-209
Antal sider	7
ISSN	1525-7770
DOI	https://doi.org/10.1080/15257770.2011.563765
Status	Udgivet - 2011

Emneord

thymidin kinase 2
Mathematical model

Link til dokument

10.1080/15257770.2011.563765

Citer dette

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abstract = "_ The mitochondrial enzyme thymidine kinase 2 (TK2) phosphorylates deoxythymidine (dT) and deoxycytidine (dC) to form dTMP and dCMP, which in cells rapidly become the negative-feedback end-products dTTP and dCTP. TK2 kinetic activity exhibits Hill coefficients of ∼0.5 (apparent negative cooperativity) for dT and ∼1 for dC. We present a mathematical model of TK2 activity that is applicable if TK2 exists as two monomer forms in equilibrium.",

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AU - Wang, Liya

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AB - _ The mitochondrial enzyme thymidine kinase 2 (TK2) phosphorylates deoxythymidine (dT) and deoxycytidine (dC) to form dTMP and dCMP, which in cells rapidly become the negative-feedback end-products dTTP and dCTP. TK2 kinetic activity exhibits Hill coefficients of ∼0.5 (apparent negative cooperativity) for dT and ∼1 for dC. We present a mathematical model of TK2 activity that is applicable if TK2 exists as two monomer forms in equilibrium.

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