A mathematical model of human thymidine kinase 2 activity

Tom Radivoyevitch, Birgitte Munch-Petersen, Liya Wang, Staffan Eriksson

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

    Abstract

    _ The mitochondrial enzyme thymidine kinase 2 (TK2) phosphorylates deoxythymidine (dT) and deoxycytidine (dC) to form dTMP and dCMP, which in cells rapidly become the negative-feedback end-products dTTP and dCTP. TK2 kinetic activity exhibits Hill coefficients of ∼0.5 (apparent negative cooperativity) for dT and ∼1 for dC. We present a mathematical model of TK2 activity that is applicable if TK2 exists as two monomer forms in equilibrium.
    OriginalsprogEngelsk
    TidsskriftNucleosides, Nucleotides and Nucleic Acids
    Vol/bind30
    Udgave nummer3
    Sider (fra-til)203-209
    Antal sider7
    ISSN1525-7770
    DOI
    StatusUdgivet - 2011

    Emneord

    • thymidin kinase 2
    • Mathematical model

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