A comparison of adolescent- and adult-onset first-episode, non-affective psychosis: 2-year follow-up.

Erik Simonsen, Johannes Langeveld, Inge Joa, Svein Friis, Wenche ten Velden Hegelstad, Ingrid Melle, Jan Olav Johannessen, Stein Opjordsmoen, Per Vaglum, B Auestad, Thomas McGlashan, Tor Ketil Larsen

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    Resumé

    This study aimed to compare 2-year outcome among individuals with early-onset (EO; <18 years) versus adult-onset (AO) first-episode, non-affective psychosis. We compared clinical and treatment characteristics of 43 EO and 189 AO patients 2 years after their inclusion in a clinical epidemiologic population-based cohort study of first-episode psychosis. Outcome variables included symptom severity, remission status, drug abuse, treatment utilization, cognition and social functioning. At baseline, EO patients were more symptomatically compromised. However, these initial baseline differences were no longer significant at the 2-year follow-up. This study challenges the findings of a larger and older literature base consisting primarily of non-comparative studies concluding that teenage onset indicates a poor outcome. Our results indicate that adolescent-onset and adult-onset psychosis have similar prognostic trajectories, although both may predict a qualitatively different course from childhood-onset psychosis.
    OriginalsprogEngelsk
    TidsskriftEuropean Archives of Psychiatry and Clinical Neuroscience
    Vol/bind262
    Udgave nummer7
    Sider (fra-til)599-605
    ISSN0940-1334
    DOI
    StatusUdgivet - 2012

    Citer dette

    Simonsen, Erik ; Langeveld, Johannes ; Joa, Inge ; Friis, Svein ; Hegelstad, Wenche ten Velden ; Melle, Ingrid ; Johannessen, Jan Olav ; Opjordsmoen, Stein ; Vaglum, Per ; Auestad, B ; McGlashan, Thomas ; Larsen, Tor Ketil. / A comparison of adolescent- and adult-onset first-episode, non-affective psychosis: 2-year follow-up. I: European Archives of Psychiatry and Clinical Neuroscience. 2012 ; Bind 262, Nr. 7. s. 599-605.
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    title = "A comparison of adolescent- and adult-onset first-episode, non-affective psychosis: 2-year follow-up.",
    abstract = "This study aimed to compare 2-year outcome among individuals with early-onset (EO; <18 years) versus adult-onset (AO) first-episode, non-affective psychosis. We compared clinical and treatment characteristics of 43 EO and 189 AO patients 2 years after their inclusion in a clinical epidemiologic population-based cohort study of first-episode psychosis. Outcome variables included symptom severity, remission status, drug abuse, treatment utilization, cognition and social functioning. At baseline, EO patients were more symptomatically compromised. However, these initial baseline differences were no longer significant at the 2-year follow-up. This study challenges the findings of a larger and older literature base consisting primarily of non-comparative studies concluding that teenage onset indicates a poor outcome. Our results indicate that adolescent-onset and adult-onset psychosis have similar prognostic trajectories, although both may predict a qualitatively different course from childhood-onset psychosis.",
    author = "Erik Simonsen and Johannes Langeveld and Inge Joa and Svein Friis and Hegelstad, {Wenche ten Velden} and Ingrid Melle and Johannessen, {Jan Olav} and Stein Opjordsmoen and Per Vaglum and B Auestad and Thomas McGlashan and Larsen, {Tor Ketil}",
    year = "2012",
    doi = "10.1007/s00406-012-0308-9",
    language = "English",
    volume = "262",
    pages = "599--605",
    journal = "European Archives of Psychiatry and Clinical Neuroscience",
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    Simonsen, E, Langeveld, J, Joa, I, Friis, S, Hegelstad, WTV, Melle, I, Johannessen, JO, Opjordsmoen, S, Vaglum, P, Auestad, B, McGlashan, T & Larsen, TK 2012, 'A comparison of adolescent- and adult-onset first-episode, non-affective psychosis: 2-year follow-up.', European Archives of Psychiatry and Clinical Neuroscience, bind 262, nr. 7, s. 599-605. https://doi.org/10.1007/s00406-012-0308-9

    A comparison of adolescent- and adult-onset first-episode, non-affective psychosis: 2-year follow-up. / Simonsen, Erik; Langeveld, Johannes; Joa, Inge; Friis, Svein; Hegelstad, Wenche ten Velden; Melle, Ingrid; Johannessen, Jan Olav; Opjordsmoen, Stein; Vaglum, Per; Auestad, B; McGlashan, Thomas; Larsen, Tor Ketil.

    I: European Archives of Psychiatry and Clinical Neuroscience, Bind 262, Nr. 7, 2012, s. 599-605.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    TY - JOUR

    T1 - A comparison of adolescent- and adult-onset first-episode, non-affective psychosis: 2-year follow-up.

    AU - Simonsen, Erik

    AU - Langeveld, Johannes

    AU - Joa, Inge

    AU - Friis, Svein

    AU - Hegelstad, Wenche ten Velden

    AU - Melle, Ingrid

    AU - Johannessen, Jan Olav

    AU - Opjordsmoen, Stein

    AU - Vaglum, Per

    AU - Auestad, B

    AU - McGlashan, Thomas

    AU - Larsen, Tor Ketil

    PY - 2012

    Y1 - 2012

    N2 - This study aimed to compare 2-year outcome among individuals with early-onset (EO; <18 years) versus adult-onset (AO) first-episode, non-affective psychosis. We compared clinical and treatment characteristics of 43 EO and 189 AO patients 2 years after their inclusion in a clinical epidemiologic population-based cohort study of first-episode psychosis. Outcome variables included symptom severity, remission status, drug abuse, treatment utilization, cognition and social functioning. At baseline, EO patients were more symptomatically compromised. However, these initial baseline differences were no longer significant at the 2-year follow-up. This study challenges the findings of a larger and older literature base consisting primarily of non-comparative studies concluding that teenage onset indicates a poor outcome. Our results indicate that adolescent-onset and adult-onset psychosis have similar prognostic trajectories, although both may predict a qualitatively different course from childhood-onset psychosis.

    AB - This study aimed to compare 2-year outcome among individuals with early-onset (EO; <18 years) versus adult-onset (AO) first-episode, non-affective psychosis. We compared clinical and treatment characteristics of 43 EO and 189 AO patients 2 years after their inclusion in a clinical epidemiologic population-based cohort study of first-episode psychosis. Outcome variables included symptom severity, remission status, drug abuse, treatment utilization, cognition and social functioning. At baseline, EO patients were more symptomatically compromised. However, these initial baseline differences were no longer significant at the 2-year follow-up. This study challenges the findings of a larger and older literature base consisting primarily of non-comparative studies concluding that teenage onset indicates a poor outcome. Our results indicate that adolescent-onset and adult-onset psychosis have similar prognostic trajectories, although both may predict a qualitatively different course from childhood-onset psychosis.

    U2 - 10.1007/s00406-012-0308-9

    DO - 10.1007/s00406-012-0308-9

    M3 - Journal article

    VL - 262

    SP - 599

    EP - 605

    JO - European Archives of Psychiatry and Clinical Neuroscience

    JF - European Archives of Psychiatry and Clinical Neuroscience

    SN - 0940-1334

    IS - 7

    ER -