Longterm investigation of resveratol on management of metabolic syndrome osteoporosis, inflammation, and identification of plant derived anti-inflammatory compounds

  • Pedersen, Steen B. (Projektkoordinator)
  • Grønbæk, Henning (Projektdeltager)
  • Enghild, Jan Johannes (Projektdeltager)
  • Vang, Ole (Projektdeltager)
  • Christensen, Lars Porskjær (Projektdeltager)
  • Grunert, Klaus G. (Projektdeltager)

    Projekter: ProjektForskning

    Projektdetaljer

    Beskrivelse

    Low-grade inflammation is associated with type 2 diabetes, non-alcoholic fatty liver disease (NAFLD), non alcoholic steatohepatitis (NASH) and osteoporosis. In animals resveratrol (found in grapes, berries etc.) has strong anti-inflammatory effects and is a promising compound with the potential to neutralize obesity-induced diseases and osteoporosis. However, the health promoting effects of resveratrol in humans are only studied sparsely. The present project focuses on the effect of resveratrol on insulin sensitivity, inflammation, bone and fatty liver disease in a long term study in humans. Also resveratrol metabolites will be investigated as they may possess positive effects. The precise intra-cellular anti-inflammatory targets of resveratrol will be studied in clinical trials and in cell culture systems. Also, as all health effects presuppose a channel of delivery, consumer acceptance of delivery of resveratrol as food additive, herbal medicine or as novel food is investigated. The project is outstanding as it combines a long term clinical study of resveratrol with several state of the art techniques such as MR-spectroscopy for determination of fat infiltration in liver and skeletal muscle, real time qPCR for gene expression analysis, polaro¬graphic oxygen measurements for mitochondrial activity, SILAC for proteomics, and LC-MS/MS for quantification of resveratrol (and metabolites) in biofluids and tissues. We expect to prove that resveratrol in humans can neutralize the detrimental effect of obesity on whole body metabolism, like low grade chronic inflammation, insulin resistance and lipid infiltration-/inflammation in liver and skeletal muscle. In addition, extracts of selected vegetables, herbs and berries will be investigated for their anti-inflammatory effects on human adipose tissue to find other natural compounds that may be useful to prevent low-grade inflammation seen in association with obesity.
    AkronymLIRMOI
    StatusAfsluttet
    Effektiv start/slut dato01/01/201131/12/2014

    Emneord

    • Resveratrol
    • knogleskørhed
    • fedme
    • inflammation

    Publikationer

    • 2 Tidsskriftartikel

    Challenges in Analyzing the Biological Effects of Resveratrol

    Erdogan, C. S. & Vang, O., 9 jun. 2016, I : Nutrients. 8, 6, 353.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    Åben adgang
    Fil

    What is new for resveratrol? Is a new set of recommendations necessary?

    Vang, O., 2013, I : New York Academy of Sciences. Annals. 1290, s. 1-11 11 s.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    Fil

    Aktiviteter

    • 1 Organisation og deltagelse i konference

    Resveratrol2014

    Ole Vang (Arrangør)

    30 nov. 20143 dec. 2014

    Aktivitet: Deltagelse i eller arrangering af en begivenhedOrganisation og deltagelse i konference